8AHF

PAC-FragmentDEL: Photoactivated covalent capture of DNA encoded fragments for hit discovery

8AHF の概要

• エントリーDOI: 10.2210/pdb8ahf/pdb
• 分子名称: UDP-N-acetylglucosamine 2-epimerase, (2~{R},4~{S})-4-[bis(fluoranyl)methoxy]-~{N}-methyl-1-(2~{H}-pyrazolo[4,3-b]pyridin-6-ylcarbonyl)pyrrolidine-2-carboxamide, SULFATE ION, ... (4 entities in total)
• 機能のキーワード: inhibitor, complex, epimerase, technology, isomerase
• 由来する生物種: Bacillus anthracis
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 85571.25

構造登録者

Baker, L.M.,Murray, J.B.,Hubbard, R.E. (登録日: 2022-07-21, 公開日: 2022-09-14, 最終更新日: 2024-01-31)

• 主引用文献: Ma, H.,Murray, J.B.,Luo, H.,Cheng, X.,Chen, Q.,Song, C.,Duan, C.,Tan, P.,Zhang, L.,Liu, J.,Morgan, B.A.,Li, J.,Wan, J.,Baker, L.M.,Finnie, W.,Guetzoyan, L.,Harris, R.,Hendrickson, N.,Matassova, N.,Simmonite, H.,Smith, J.,Hubbard, R.E.,Liu, G.; PAC-FragmentDEL - photoactivated covalent capture of DNA-encoded fragments for hit discovery.; Rsc Med Chem, 13:1341-1349, 2022; PubMed: 36426238; DOI: 10.1039/d2md00197g

実験手法

X-RAY DIFFRACTION (2.271 Å)