8AEM
Structure of Compound 13 bound to CK2alpha
Summary for 8AEM
Entry DOI | 10.2210/pdb8aem/pdb |
Descriptor | Casein kinase II subunit alpha, ACETATE ION, 2-(5-chloranyl-1H-indol-3-yl)ethanenitrile, ... (5 entities in total) |
Functional Keywords | fragment based, transferase |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 1 |
Total formula weight | 40083.47 |
Authors | Brear, P.,Fusco, C.,Atkinson, E.,Iegre, J.,Francis-Newton, N.,Venkotaraman, A.,Spring, D.,Hyvonen, M. (deposition date: 2022-07-13, release date: 2023-03-29, Last modification date: 2024-02-07) |
Primary citation | Brear, P.,De Fusco, C.,Atkinson, E.L.,Iegre, J.,Francis-Newton, N.J.,Venkitaraman, A.R.,Hyvonen, M.,Spring, D.R. A fragment-based approach leading to the discovery of inhibitors of CK2 alpha with a novel mechanism of action. Rsc Med Chem, 13:1420-1426, 2022 Cited by PubMed: 36426237DOI: 10.1039/d2md00161f PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.6 Å) |
Structure validation
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