8AB5
Structure of E. coli GlpG in complex with peptide derived inhibitor Ac-VRHA-conh-[4-(4-butyl)-phenoxy-1-phenyl-2-butyl]
Summary for 8AB5
Entry DOI | 10.2210/pdb8ab5/pdb |
Related PRD ID | PRD_002417 |
Descriptor | Rhomboid protease GlpG, Ac-VRHA-conh-[4-(4-butyl)-phenoxy-1-phenyl-2-butyl] (3 entities in total) |
Functional Keywords | rhomboid, protease, glpg, ketoamide, inhibitor, hydrolase |
Biological source | Escherichia coli K-12 More |
Total number of polymer chains | 4 |
Total formula weight | 42324.36 |
Authors | Skerlova, J.,Polovinkin, V.,Bach, K.,Borshchevskiy, V.,Strisovsky, K. (deposition date: 2022-07-04, release date: 2023-10-25, Last modification date: 2024-07-10) |
Primary citation | Bach, K.,Dohnalek, J.,Skerlova, J.,Kuzmik, J.,Polachova, E.,Stanchev, S.,Majer, P.,Fanfrlik, J.,Pecina, A.,Rezac, J.,Lepsik, M.,Borshchevskiy, V.,Polovinkin, V.,Strisovsky, K. Extensive targeting of chemical space at the prime side of ketoamide inhibitors of rhomboid proteases by branched substituents empowers their selectivity and potency. Eur.J.Med.Chem., 275:116606-116606, 2024 Cited by PubMed: 38901105DOI: 10.1016/j.ejmech.2024.116606 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.4 Å) |
Structure validation
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