8AB5

Structure of E. coli GlpG in complex with peptide derived inhibitor Ac-VRHA-conh-[4-(4-butyl)-phenoxy-1-phenyl-2-butyl]

Summary for 8AB5

Entry DOI	10.2210/pdb8ab5/pdb
Related PRD ID	PRD_002417
Descriptor	Rhomboid protease GlpG, Ac-VRHA-conh-[4-(4-butyl)-phenoxy-1-phenyl-2-butyl] (3 entities in total)
Functional Keywords	rhomboid, protease, glpg, ketoamide, inhibitor, hydrolase
Biological source	Escherichia coli K-12 More
Total number of polymer chains	4
Total formula weight	42324.36
Authors	Skerlova, J.,Polovinkin, V.,Bach, K.,Borshchevskiy, V.,Strisovsky, K. (deposition date: 2022-07-04, release date: 2023-10-25, Last modification date: 2024-07-10)
Primary citation	Bach, K.,Dohnalek, J.,Skerlova, J.,Kuzmik, J.,Polachova, E.,Stanchev, S.,Majer, P.,Fanfrlik, J.,Pecina, A.,Rezac, J.,Lepsik, M.,Borshchevskiy, V.,Polovinkin, V.,Strisovsky, K. Extensive targeting of chemical space at the prime side of ketoamide inhibitors of rhomboid proteases by branched substituents empowers their selectivity and potency. Eur.J.Med.Chem., 275:116606-116606, 2024 Cited by PubMed: 38901105 DOI: 10.1016/j.ejmech.2024.116606 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.4 Å)

Structure validation