8AB5

Structure of E. coli GlpG in complex with peptide derived inhibitor Ac-VRHA-conh-[4-(4-butyl)-phenoxy-1-phenyl-2-butyl]

8AB5 の概要

• エントリーDOI: 10.2210/pdb8ab5/pdb
• 関連するBIRD辞書のPRD_ID: PRD_002417
• 分子名称: Rhomboid protease GlpG, Ac-VRHA-conh-[4-(4-butyl)-phenoxy-1-phenyl-2-butyl] (3 entities in total)
• 機能のキーワード: rhomboid, protease, glpg, ketoamide, inhibitor, hydrolase
• 由来する生物種: Escherichia coli K-12; 詳細
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 42324.36

構造登録者

Skerlova, J.,Polovinkin, V.,Bach, K.,Borshchevskiy, V.,Strisovsky, K. (登録日: 2022-07-04, 公開日: 2023-10-25, 最終更新日: 2024-07-10)

• 主引用文献: Bach, K.,Dohnalek, J.,Skerlova, J.,Kuzmik, J.,Polachova, E.,Stanchev, S.,Majer, P.,Fanfrlik, J.,Pecina, A.,Rezac, J.,Lepsik, M.,Borshchevskiy, V.,Polovinkin, V.,Strisovsky, K.; Extensive targeting of chemical space at the prime side of ketoamide inhibitors of rhomboid proteases by branched substituents empowers their selectivity and potency.; Eur.J.Med.Chem., 275:116606-116606, 2024; PubMed: 38901105; DOI: 10.1016/j.ejmech.2024.116606

実験手法

X-RAY DIFFRACTION (2.4 Å)