8AAA

Crystal structure of SARS-CoV-2 S RBD in complex with a stapled peptide

8AAA の概要

• エントリーDOI: 10.2210/pdb8aaa/pdb
• 分子名称: Spike protein S1, Stapled peptide, 1,1',1''-(1,3,5-triazinane-1,3,5-triyl)tripropan-1-one, ... (4 entities in total)
• 機能のキーワード: srbd, stapled peptide, viral protein
• 由来する生物種: Severe acute respiratory syndrome coronavirus 2; 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 24092.21

構造登録者

Brear, P.,Chen, L.,Gaynor, K.,Harman, M.,Dods, R.,Hyvonen, M. (登録日: 2022-06-30, 公開日: 2023-06-28, 最終更新日: 2024-02-07)

• 主引用文献: Gaynor, K.U.,Vaysburd, M.,Harman, M.A.J.,Albecka, A.,Jeffrey, P.,Beswick, P.,Papa, G.,Chen, L.,Mallery, D.,McGuinness, B.,Van Rietschoten, K.,Stanway, S.,Brear, P.,Lulla, A.,Ciazynska, K.,Chang, V.T.,Sharp, J.,Neary, M.,Box, H.,Herriott, J.,Kijak, E.,Tatham, L.,Bentley, E.G.,Sharma, P.,Kirby, A.,Han, X.,Stewart, J.P.,Owen, A.,Briggs, J.A.G.,Hyvonen, M.,Skynner, M.J.,James, L.C.; Multivalent bicyclic peptides are an effective antiviral modality that can potently inhibit SARS-CoV-2.; Nat Commun, 14:3583-3583, 2023; PubMed: 37328472; DOI: 10.1038/s41467-023-39158-1

実験手法

X-RAY DIFFRACTION (1.9 Å)