8A9Z

Tubulin-[1,2]oxazoloisoindole-2e complex

8A9Z の概要

• エントリーDOI: 10.2210/pdb8a9z/pdb
• 分子名称: Tubulin alpha-1B chain, 7-[(3,5-dimethoxyphenyl)methyl]pyrrolo[3,4-g][1,2]benzoxazole, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, ... (12 entities in total)
• 機能のキーワード: cell cycle, tubulin fold, cytoskeleton, microtubule
• 由来する生物種: Rattus norvegicus (Norway rat); 詳細
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 265178.80

構造登録者

Prota, A.E.,Abel, A.-C.,Steinmetz, M.O.,Barraja, P.,Montalbano, A.,Spano, V. (登録日: 2022-06-29, 公開日: 2022-11-09, 最終更新日: 2024-01-31)

• 主引用文献: Barreca, M.,Spano, V.,Rocca, R.,Bivacqua, R.,Abel, A.C.,Maruca, A.,Montalbano, A.,Raimondi, M.V.,Tarantelli, C.,Gaudio, E.,Cascione, L.,Rinaldi, A.,Bai, R.,Steinmetz, M.O.,Prota, A.E.,Alcaro, S.,Hamel, E.,Bertoni, F.,Barraja, P.; Development of [1,2]oxazoloisoindoles tubulin polymerization inhibitors: Further chemical modifications and potential therapeutic effects against lymphomas.; Eur.J.Med.Chem., 243:114744-114744, 2022; PubMed: 36242921; DOI: 10.1016/j.ejmech.2022.114744

実験手法

X-RAY DIFFRACTION (2.294 Å)