8A46

Crystal structure of the human Kelch domain of Keap1 in complex with compound S217879

8A46 の概要

• エントリーDOI: 10.2210/pdb8a46/pdb
• 分子名称: Kelch-like ECH-associated protein 1, 2-[(1S,2R,8S)-2,4,32-trimethyl-28,28-bis(oxidanylidene)-19,22,27-trioxa-28$l^{6}-thia-1,14,15,16-tetrazahexacyclo[21.5.3.1^{3,7}.1^{9,13}.0^{12,16}.0^{26,30}]tritriaconta-3(33),4,6,9(32),10,12,14,23,25,30-decaen-8-yl]ethanoic acid (3 entities in total)
• 機能のキーワード: master regulator of cellular resistance to oxidants, transcription
• 由来する生物種: Mus musculus (house mouse)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 34368.43

構造登録者

Weber, C.,Vuillard, L.,Delerive, P.,Miallau, L. (登録日: 2022-06-10, 公開日: 2022-07-13, 最終更新日: 2024-05-01)

• 主引用文献: Seedorf, K.,Weber, C.,Vinson, C.,Berger, S.,Vuillard, L.M.,Kiss, A.,Creusot, S.,Broux, O.,Geant, A.,Ilic, C.,Lemaitre, K.,Richard, J.,Hammoutene, A.,Mahieux, J.,Martiny, V.,Durand, D.,Melchiore, F.,Nyerges, M.,Paradis, V.,Provost, N.,Duvivier, V.,Delerive, P.; Selective disruption of NRF2-KEAP1 interaction leads to NASH resolution and reduction of liver fibrosis in mice.; JHEP Rep, 5:100651-100651, 2023; PubMed: 36866391; DOI: 10.1016/j.jhepr.2022.100651

実験手法

X-RAY DIFFRACTION (1.323 Å)