8A31

p53 cancer mutant Y220C in complex with iodophenol-based small-molecule stabilizer JC694

8A31 の概要

• エントリーDOI: 10.2210/pdb8a31/pdb
• 分子名称: Cellular tumor antigen p53, 4-(3-fluoranylpyrrol-1-yl)-3,5-bis(iodanyl)-2-oxidanyl-benzoic acid, ZINC ION, ... (5 entities in total)
• 機能のキーワード: tumor suppressor p53, cancer mutant, drug discovery, small-molecule stabilizer, transcription
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 50230.49

構造登録者

Balourdas, D.I.,Stephenson Clarke, J.R.,Baud, M.G.J.,Knapp, S.,Joerger, A.C.,Structural Genomics Consortium (SGC) (登録日: 2022-06-06, 公開日: 2022-11-30, 最終更新日: 2024-01-31)

• 主引用文献: Stephenson Clarke, J.R.,Douglas, L.R.,Duriez, P.J.,Balourdas, D.I.,Joerger, A.C.,Khadiullina, R.,Bulatov, E.,Baud, M.G.J.; Discovery of Nanomolar-Affinity Pharmacological Chaperones Stabilizing the Oncogenic p53 Mutant Y220C.; Acs Pharmacol Transl Sci, 5:1169-1180, 2022; PubMed: 36407959; DOI: 10.1021/acsptsci.2c00164

実験手法

X-RAY DIFFRACTION (1.46 Å)