8A1M
Crystal structure of the transpeptidase LdtMt2 from Mycobacterium tuberculosis in complex with maleimide analogue 4
Summary for 8A1M
Entry DOI | 10.2210/pdb8a1m/pdb |
Descriptor | L,D-transpeptidase 2, 1-(2-fluoranyl-5-methylsulfonyl-phenyl)pyrrolidine-2,5-dione, 1,2-ETHANEDIOL, ... (8 entities in total) |
Functional Keywords | l, d-transpeptidase, ldtmt2, inhibitor, covalent, antimicrobial protein |
Biological source | Mycobacterium tuberculosis |
Total number of polymer chains | 2 |
Total formula weight | 77440.56 |
Authors | de Munnik, M.,Lang, P.A.,Brem, J.,Schofield, C.J. (deposition date: 2022-06-01, release date: 2023-06-14, Last modification date: 2024-02-07) |
Primary citation | de Munnik, M.,Lang, P.A.,De Dios Anton, F.,Cacho, M.,Bates, R.H.,Brem, J.,Rodriguez Miquel, B.,Schofield, C.J. High-throughput screen with the l,d-transpeptidase Ldt Mt2 of Mycobacterium tuberculosis reveals novel classes of covalently reacting inhibitors. Chem Sci, 14:7262-7278, 2023 Cited by PubMed: 37416715DOI: 10.1039/d2sc06858c PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.3 Å) |
Structure validation
Download full validation report