8A0L
Tubulin-CW1-complex
Summary for 8A0L
Entry DOI | 10.2210/pdb8a0l/pdb |
Descriptor | Tubulin alpha-1B chain, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, (3~{S},4~{R},8~{S},10~{S},12~{S},14~{S})-14-[(~{Z},4~{R})-4-(hydroxymethyl)hex-2-en-2-yl]-4,12-dimethoxy-9,9-dimethyl-3,8,10-tris(oxidanyl)-1-oxacyclotetradecan-2-one, ... (13 entities in total) |
Functional Keywords | cell cycle, tubulin fold, cytoskeleton, microtubule |
Biological source | Rattus norvegicus (Norway rat) More |
Total number of polymer chains | 6 |
Total formula weight | 265166.85 |
Authors | Prota, A.E.,Diaz, J.F.,Steinmetz, M.O.,Oliva, M.A. (deposition date: 2022-05-28, release date: 2022-12-14, Last modification date: 2024-01-31) |
Primary citation | Estevez-Gallego, J.,Alvarez-Bernad, B.,Pera, B.,Wullschleger, C.,Raes, O.,Menche, D.,Martinez, J.C.,Lucena-Agell, D.,Prota, A.E.,Bonato, F.,Bargsten, K.,Cornelus, J.,Gimenez-Abian, J.F.,Northcote, P.,Steinmetz, M.O.,Kamimura, S.,Altmann, K.H.,Paterson, I.,Gago, F.,Van der Eycken, J.,Diaz, J.F.,Oliva, M.A. Chemical modulation of microtubule structure through the laulimalide/peloruside site. Structure, 31:88-99.e5, 2023 Cited by PubMed: 36462501DOI: 10.1016/j.str.2022.11.006 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.9981 Å) |
Structure validation
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