8A0L

Tubulin-CW1-complex

Summary for 8A0L

• Entry DOI: 10.2210/pdb8a0l/pdb
• Descriptor: Tubulin alpha-1B chain, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, (3~{S},4~{R},8~{S},10~{S},12~{S},14~{S})-14-[(~{Z},4~{R})-4-(hydroxymethyl)hex-2-en-2-yl]-4,12-dimethoxy-9,9-dimethyl-3,8,10-tris(oxidanyl)-1-oxacyclotetradecan-2-one, ... (13 entities in total)
• Functional Keywords: cell cycle, tubulin fold, cytoskeleton, microtubule
• Biological source: Rattus norvegicus (Norway rat); More
• Total number of polymer chains: 6
• Total formula weight: 265166.85

Authors

Prota, A.E.,Diaz, J.F.,Steinmetz, M.O.,Oliva, M.A. (deposition date: 2022-05-28, release date: 2022-12-14, Last modification date: 2024-01-31)

• Primary citation: Estevez-Gallego, J.,Alvarez-Bernad, B.,Pera, B.,Wullschleger, C.,Raes, O.,Menche, D.,Martinez, J.C.,Lucena-Agell, D.,Prota, A.E.,Bonato, F.,Bargsten, K.,Cornelus, J.,Gimenez-Abian, J.F.,Northcote, P.,Steinmetz, M.O.,Kamimura, S.,Altmann, K.H.,Paterson, I.,Gago, F.,Van der Eycken, J.,Diaz, J.F.,Oliva, M.A.; Chemical modulation of microtubule structure through the laulimalide/peloruside site.; Structure, 31:88-99.e5, 2023; PubMed: 36462501; DOI: 10.1016/j.str.2022.11.006

Experimental method

X-RAY DIFFRACTION (1.9981 Å)