8A00

Infectious mouse-adapted ME7 scrapie prion fibril purified from terminally-infected mouse brains

Summary for 8A00

Entry DOI	10.2210/pdb8a00/pdb
EMDB information	15043
Descriptor	Major prion protein (1 entity in total)
Functional Keywords	prion, protein fibril
Biological source	Mus musculus (house mouse)
Total number of polymer chains	3
Total formula weight	47329.89
Authors	Manka, S.W.,Wenborn, A.,Betts, J.,Joiner, S.,Saibil, H.R.,Collinge, J.,Wadsworth, J.D.F. (deposition date: 2022-05-26, release date: 2023-01-18, Last modification date: 2023-05-10)
Primary citation	Manka, S.W.,Wenborn, A.,Betts, J.,Joiner, S.,Saibil, H.R.,Collinge, J.,Wadsworth, J.D.F. A structural basis for prion strain diversity. Nat.Chem.Biol., 19:607-613, 2023 Cited by PubMed: 36646960 DOI: 10.1038/s41589-022-01229-7 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (2.6 Å)

Structure validation