8EST
REACTION OF PORCINE PANCREATIC ELASTASE WITH 7-SUBSTITUTED 3-ALKOXY-4-CHLOROISOCOUMARINS: DESIGN OF POTENT INHIBITORS USING THE CRYSTAL STRUCTURE OF THE COMPLEX FORMED WITH 4-CHLORO-3-ETHOXY-7-GUANIDINO-ISOCOUMARIN
Summary for 8EST
Entry DOI | 10.2210/pdb8est/pdb |
Descriptor | PORCINE PANCREATIC ELASTASE, SULFATE ION, CALCIUM ION, ... (5 entities in total) |
Functional Keywords | hydrolase(serine proteinase) |
Biological source | Sus scrofa (pig) |
Cellular location | Secreted: P00772 |
Total number of polymer chains | 1 |
Total formula weight | 26363.88 |
Authors | Radhakrishnan, R.,Powers, J.C.,Meyerjunior, E.F. (deposition date: 1990-02-21, release date: 1992-10-15, Last modification date: 2024-06-05) |
Primary citation | Powers, J.C.,Oleksyszyn, J.,Narasimhan, S.L.,Kam, C.M. Reaction of porcine pancreatic elastase with 7-substituted 3-alkoxy-4-chloroisocoumarins: design of potent inhibitors using the crystal structure of the complex formed with 4-chloro-3-ethoxy-7-guanidinoisocoumarin. Biochemistry, 29:3108-3118, 1990 Cited by PubMed: 2337582DOI: 10.1021/bi00464a030 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.78 Å) |
Structure validation
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