7ZZW

Ligand binding to HDAC2

Summary for 7ZZW

Entry DOI	10.2210/pdb7zzw/pdb
Descriptor	Histone deacetylase 2, DI(HYDROXYETHYL)ETHER, TETRAETHYLENE GLYCOL, ... (10 entities in total)
Functional Keywords	protein deacetylation, transcriptional repressor complex, chromatin binding, transcription
Biological source	Homo sapiens (human)
Total number of polymer chains	3
Total formula weight	173102.21
Authors	Cleasby, A.,Tisi, D. (deposition date: 2022-05-26, release date: 2022-09-21, Last modification date: 2024-06-19)
Primary citation	Tamanini, E.,Miyamura, S.,Buck, I.M.,Cons, B.D.,Dawson, L.,East, C.,Futamura, T.,Goto, S.,Griffiths-Jones, C.,Hashimoto, T.,Heightman, T.D.,Ishikawa, S.,Ito, H.,Kaneko, Y.,Kawato, T.,Kondo, K.,Kurihara, N.,McCarthy, J.M.,Mori, Y.,Nagase, T.,Nakaishi, Y.,Reeks, J.,Sato, A.,Schopf, P.,Tai, K.,Tamai, T.,Tisi, D.,Woolford, A.J. Fragment-Based Discovery of a Novel, Brain Penetrant, Orally Active HDAC2 Inhibitor. Acs Med.Chem.Lett., 13:1591-1597, 2022 Cited by PubMed: 36262388 DOI: 10.1021/acsmedchemlett.2c00272 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.73 Å)

Structure validation