7ZYQ

Crystal Structure of EGFR-T790M/V948R in Complex with Reversible Aminopyrimidine 13

Summary for 7ZYQ

• Entry DOI: 10.2210/pdb7zyq/pdb
• Descriptor: Epidermal growth factor receptor, phenyl 2-[[4-[4-(dimethylamino)piperidin-1-yl]-2-methoxy-phenyl]amino]-4-(1H-indol-3-yl)pyrimidine-5-carboxylate, SULFATE ION, ... (6 entities in total)
• Functional Keywords: egfr, t790m/v948r, inhibitor, transferase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 77531.29

Authors

Niggenaber, J.,Mueller, M.P.,Rauh, D. (deposition date: 2022-05-25, release date: 2023-05-03, Last modification date: 2024-02-07)

• Primary citation: Grabe, T.,Jeyakumar, K.,Niggenaber, J.,Schulz, T.,Koska, S.,Kleinbolting, S.,Beck, M.E.,Muller, M.P.,Rauh, D.; Addressing the Osimertinib Resistance Mutation EGFR-L858R/C797S with Reversible Aminopyrimidines.; Acs Med.Chem.Lett., 14:591-598, 2023; PubMed: 37197473; DOI: 10.1021/acsmedchemlett.2c00514

Experimental method

X-RAY DIFFRACTION (2.1 Å)