7ZYQ
Crystal Structure of EGFR-T790M/V948R in Complex with Reversible Aminopyrimidine 13
Summary for 7ZYQ
Entry DOI | 10.2210/pdb7zyq/pdb |
Descriptor | Epidermal growth factor receptor, phenyl 2-[[4-[4-(dimethylamino)piperidin-1-yl]-2-methoxy-phenyl]amino]-4-(1H-indol-3-yl)pyrimidine-5-carboxylate, SULFATE ION, ... (6 entities in total) |
Functional Keywords | egfr, t790m/v948r, inhibitor, transferase |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 2 |
Total formula weight | 77531.29 |
Authors | Niggenaber, J.,Mueller, M.P.,Rauh, D. (deposition date: 2022-05-25, release date: 2023-05-03, Last modification date: 2024-02-07) |
Primary citation | Grabe, T.,Jeyakumar, K.,Niggenaber, J.,Schulz, T.,Koska, S.,Kleinbolting, S.,Beck, M.E.,Muller, M.P.,Rauh, D. Addressing the Osimertinib Resistance Mutation EGFR-L858R/C797S with Reversible Aminopyrimidines. Acs Med.Chem.Lett., 14:591-598, 2023 Cited by PubMed: 37197473DOI: 10.1021/acsmedchemlett.2c00514 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.1 Å) |
Structure validation
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