7ZYD

Structure of Compound 6 Bound to CK2alpha

Summary for 7ZYD

Entry DOI	10.2210/pdb7zyd/pdb
Descriptor	Casein kinase II subunit alpha, ACETATE ION, ADENOSINE-5'-TRIPHOSPHATE, ... (5 entities in total)
Functional Keywords	fragment based drug discovery, transferase
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	39887.15
Authors	Brear, P.,Hyvonen, M. (deposition date: 2022-05-24, release date: 2022-10-12, Last modification date: 2024-01-31)
Primary citation	Brear, P.,De Fusco, C.,Atkinson, E.L.,Iegre, J.,Francis-Newton, N.J.,Venkitaraman, A.R.,Hyvonen, M.,Spring, D.R. A fragment-based approach leading to the discovery of inhibitors of CK2 alpha with a novel mechanism of action. Rsc Med Chem, 13:1420-1426, 2022 Cited by PubMed: 36426237 DOI: 10.1039/d2md00161f PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.404 Å)

Structure validation