7ZWV
Crystal structure of human BCL6 BTB domain in complex with compound 17
7ZWV の概要
エントリーDOI | 10.2210/pdb7zwv/pdb |
分子名称 | B-cell lymphoma 6 protein, ALA-TRP-VAL-ILE-PRO-ALA, 1,3-dimethyl-5-[[6-(phenylmethylsulfanyl)pyrimidin-4-yl]amino]benzimidazol-2-one, ... (7 entities in total) |
機能のキーワード | inhibitor, cancer, transcription |
由来する生物種 | Homo sapiens (human) 詳細 |
タンパク質・核酸の鎖数 | 2 |
化学式量合計 | 16391.10 |
構造登録者 | Collie, G.W.,Le Bihan, Y.-V.,van Montfort, R.L.M. (登録日: 2022-05-19, 公開日: 2022-11-16, 最終更新日: 2024-01-31) |
主引用文献 | Pierrat, O.A.,Liu, M.,Collie, G.W.,Shetty, K.,Rodrigues, M.J.,Le Bihan, Y.V.,Gunnell, E.A.,McAndrew, P.C.,Stubbs, M.,Rowlands, M.G.,Yahya, N.,Shehu, E.,Talbot, R.,Pickard, L.,Bellenie, B.R.,Cheung, K.J.,Drouin, L.,Innocenti, P.,Woodward, H.,Davis, O.A.,Lloyd, M.G.,Varela, A.,Huckvale, R.,Broccatelli, F.,Carter, M.,Galiwango, D.,Hayes, A.,Raynaud, F.I.,Bryant, C.,Whittaker, S.,Rossanese, O.W.,Hoelder, S.,Burke, R.,van Montfort, R.L.M. Discovering cell-active BCL6 inhibitors: effectively combining biochemical HTS with multiple biophysical techniques, X-ray crystallography and cell-based assays. Sci Rep, 12:18633-18633, 2022 Cited by PubMed: 36329085DOI: 10.1038/s41598-022-23264-z 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (1.52 Å) |
構造検証レポート
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