7ZVV

Crystal Structure of Unlinked NS2B-NS3 Protease from Zika Virus in Complex with Inhibitor MI-2196

Summary for 7ZVV

• Entry DOI: 10.2210/pdb7zvv/pdb
• Descriptor: Serine protease subunit NS2B, Serine protease NS3, (2R)-6-azanyl-2-carbamimidamido-hexanoic acid, ... (8 entities in total)
• Functional Keywords: flavivirin, serine protease, viral protein, ns2b-ns3, zika virus
• Biological source: Zika virus; More
• Total number of polymer chains: 2
• Total formula weight: 25808.03

Authors

Huber, S.,Steinmetzer, T. (deposition date: 2022-05-17, release date: 2023-05-24, Last modification date: 2024-06-12)

• Primary citation: Huber, S.,Braun, N.J.,Schmacke, L.C.,Murra, R.,Bender, D.,Hildt, E.,Heine, A.,Steinmetzer, T.; Synthesis and structural characterization of new macrocyclic inhibitors of the Zika virus NS2B-NS3 protease.; Arch Pharm, :e2400250-e2400250, 2024; PubMed: 38809037; DOI: 10.1002/ardp.202400250

Experimental method

X-RAY DIFFRACTION (1.75 Å)