7ZV8

Crystal structure of SARS Cov-2 main protease in complex with an inhibitor 58

Summary for 7ZV8

Entry DOI	10.2210/pdb7zv8/pdb
Related PRD ID	PRD_002412
Descriptor	3C-like proteinase nsp5, inhibitor 58, DIMETHYL SULFOXIDE, ... (5 entities in total)
Functional Keywords	sars cov-2, 3cl, main protease, antiviral protein
Biological source	Severe acute respiratory syndrome coronavirus 2 More
Total number of polymer chains	4
Total formula weight	69253.36
Authors	Rahimova, R.,Di Micco, S.,Marquez, J.A. (deposition date: 2022-05-13, release date: 2022-12-07, Last modification date: 2024-02-07)
Primary citation	Di Micco, S.,Rahimova, R.,Sala, M.,Scala, M.C.,Vivenzio, G.,Musella, S.,Andrei, G.,Remans, K.,Mammri, L.,Snoeck, R.,Bifulco, G.,Di Matteo, F.,Vestuto, V.,Campiglia, P.,Marquez, J.A.,Fasano, A. Rational design of the zonulin inhibitor AT1001 derivatives as potential anti SARS-CoV-2. Eur.J.Med.Chem., 244:114857-114857, 2022 Cited by PubMed: 36332548 DOI: 10.1016/j.ejmech.2022.114857 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.937 Å)

Structure validation