7ZU6

Polyoxidovanadate interaction with proteins: crystal structure of lysozyme bound to tetra-vanadate ion (structure 1)

This is a non-PDB format compatible entry.

Summary for 7ZU6

• Entry DOI: 10.2210/pdb7zu6/pdb
• Descriptor: Lysozyme, SODIUM ION, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ... (6 entities in total)
• Functional Keywords: protein, vanadium, metallodrug, polyoxidovanadate ions, interaction, hydrolase
• Biological source: Gallus gallus (chicken)
• Total number of polymer chains: 1
• Total formula weight: 15073.17

Authors

Tito, G.,Merlino, A.,Ferraro, G. (deposition date: 2022-05-11, release date: 2023-05-24, Last modification date: 2024-10-23)

Primary citation

Ferraro, G.,Tito, G.,Sciortino, G.,Garribba, E.,Merlino, A.
Stabilization and Binding of [V 4 O 12 ] 4- and Unprecedented [V 20 O 54 (NO 3 )] n- to Lysozyme upon Loss of Ligands and Oxidation of the Potential Drug V IV O(acetylacetonato) 2.
Angew.Chem.Int.Ed.Engl., 62:e202310655-e202310655, 2023

PubMed Abstract: High-resolution crystal structures of lysozyme in the presence of the potential drug V O(acetylacetonato) under two different experimental conditions have been solved. The crystallographic study reveals the loss of the ligands, the oxidation of V to V and the subsequent formation of adducts of the protein with two different polyoxidovanadates: [V O ] , which interacts with lysozyme non-covalently, and the unprecedented [V O (NO )] , which is covalenty bound to the side chain of an aspartate residue of symmetry related molecules.

PubMed: 37768728
DOI: 10.1002/anie.202310655

Experimental method

X-RAY DIFFRACTION (1.183 Å)