7ZTM

Crystal Structure of Unlinked NS2B-NS3 Protease from Zika Virus in Complex with Inhibitor MI-2128

Summary for 7ZTM

Entry DOI	10.2210/pdb7ztm/pdb
Descriptor	Serine protease subunit NS2B, Serine protease NS3, 1-[(5R,8R,15S,18S)-15-(4-azanylbutyl)-5-(cyclohexylmethyl)-18-(naphthalen-2-ylmethyl)-4,7,14,17,20-pentakis(oxidanylidene)-3,6,13,16,19-pentazabicyclo[20.3.1]hexacosa-1(25),22(26),23-trien-8-yl]guanidine, ... (4 entities in total)
Functional Keywords	flavivirin, serine protease, viral protein, ns2b-ns3, zika virus
Biological source	Zika virus More
Total number of polymer chains	2
Total formula weight	25698.99
Authors	Huber, S.,Steinmetzer, T. (deposition date: 2022-05-10, release date: 2023-03-22, Last modification date: 2024-06-12)
Primary citation	Huber, S.,Braun, N.J.,Schmacke, L.C.,Murra, R.,Bender, D.,Hildt, E.,Heine, A.,Steinmetzer, T. Synthesis and structural characterization of new macrocyclic inhibitors of the Zika virus NS2B-NS3 protease. Arch Pharm, :e2400250-e2400250, 2024 Cited by PubMed: 38809037 DOI: 10.1002/ardp.202400250 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.45 Å)

Structure validation