7ZSP

human purine nucleoside phosphorylase in complex with JS-555

Summary for 7ZSP

Entry DOI	10.2210/pdb7zsp/pdb
Descriptor	Purine nucleoside phosphorylase, [(~{E})-2-[2-[(4-oxidanylidene-3,5-dihydropyrrolo[3,2-d]pyrimidin-7-yl)sulfanyl]-6-[2,3,4,5,6-pentakis(fluoranyl)phenoxy]phenyl]ethenyl]phosphonic acid, 6-tungstotellurate(VI), ... (5 entities in total)
Functional Keywords	pnp-inhibitor complex, transferase
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	37553.07
Authors	Djukic, S.,Pachl, P.,Rezacova, P. (deposition date: 2022-05-08, release date: 2023-05-17, Last modification date: 2024-02-07)
Primary citation	Skacel, J.,Djukic, S.,Baszczynski, O.,Kalcic, F.,Bilek, T.,Chalupsky, K.,Kozak, J.,Dvorakova, A.,Tloust'ova, E.,Kral'ova, Z.,Smidkova, M.,Voldrich, J.,Rumlova, M.,Pachl, P.,Brynda, J.,Vuckova, T.,Fabry, M.,Snasel, J.,Pichova, I.,Rezacova, P.,Mertlikova-Kaiserova, H.,Janeba, Z. Design, Synthesis, Biological Evaluation, and Crystallographic Study of Novel Purine Nucleoside Phosphorylase Inhibitors. J.Med.Chem., 66:6652-6681, 2023 Cited by PubMed: 37134237 DOI: 10.1021/acs.jmedchem.2c02097 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.29 Å)

Structure validation