7ZQ1
Crystal Structure of Unlinked NS2B-NS3 Protease from Zika Virus in Complex with Inhibitor MI-2205
Summary for 7ZQ1
Entry DOI | 10.2210/pdb7zq1/pdb |
Descriptor | Serine protease subunit NS2B, Serine protease NS3, 1-[(8R,15S,18S)-15-(4-azanylbutyl)-18-(1H-indol-3-ylmethyl)-4,7,14,17,20-pentakis(oxidanylidene)-3,6,13,16,19-pentazabicyclo[20.3.1]hexacosa-1(25),22(26),23-trien-8-yl]guanidine, ... (4 entities in total) |
Functional Keywords | flavivirin, serine protease, viral protein, ns2b-ns3, zika virus |
Biological source | Zika virus More |
Total number of polymer chains | 2 |
Total formula weight | 25591.80 |
Authors | Huber, S.,Steinmetzer, T. (deposition date: 2022-04-29, release date: 2023-03-22, Last modification date: 2024-06-12) |
Primary citation | Huber, S.,Braun, N.J.,Schmacke, L.C.,Murra, R.,Bender, D.,Hildt, E.,Heine, A.,Steinmetzer, T. Synthesis and structural characterization of new macrocyclic inhibitors of the Zika virus NS2B-NS3 protease. Arch Pharm, :e2400250-e2400250, 2024 Cited by PubMed: 38809037DOI: 10.1002/ardp.202400250 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.52 Å) |
Structure validation
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