7ZNO
Crystal Structure of Unlinked NS2B_NS3 Protease from Zika Virus in Complex with Boronate Inhibitor MI-2270
Summary for 7ZNO
Entry DOI | 10.2210/pdb7zno/pdb |
Descriptor | Serine protease subunit NS2B, Serine protease NS3, [(1R)-1-[[(2S)-6-azanyl-2-[[(2S)-6-azanyl-2-[2-[3-(4-carbamimidamido-3-oxidanylidene-pentyl)phenyl]ethanoylamino]hexanoyl]amino]hexanoyl]amino]-3-methyl-butyl]boronic acid, ... (4 entities in total) |
Functional Keywords | flavivirin, serine protease, viral protein, ns2b-ns3, zika virus, boronic acid, boronate |
Biological source | Zika virus More |
Total number of polymer chains | 2 |
Total formula weight | 25549.61 |
Authors | Huber, S.,Heine, A.,Steinmetzer, T. (deposition date: 2022-04-21, release date: 2022-06-22, Last modification date: 2024-02-07) |
Primary citation | Braun, N.J.,Huber, S.,Schmacke, L.C.,Heine, A.,Steinmetzer, T. Boroleucine-Derived Covalent Inhibitors of the ZIKV Protease. Chemmedchem, 18:e202200336-e202200336, 2023 Cited by PubMed: 36325810DOI: 10.1002/cmdc.202200336 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.7 Å) |
Structure validation
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