7ZKA

ABCB1 V978C mutant (mABCB1) in the outward facing state bound to AAC

Summary for 7ZKA

Entry DOI	10.2210/pdb7zka/pdb
EMDB information	14760
Descriptor	ATP-dependent translocase ABCB1, (4~{S},11~{S},18~{S})-4,11-dimethyl-18-(sulfanylmethyl)-6,13,20-trithia-3,10,17,22,23,24-hexazatetracyclo[17.2.1.1^{5,8}.1^{12,15}]tetracosa-1(21),5(24),7,12(23),14,19(22)-hexaene-2,9,16-trione, ADENOSINE-5'-TRIPHOSPHATE, ... (7 entities in total)
Functional Keywords	abc transporter, membrane protein
Biological source	Mus musculus (house mouse)
Total number of polymer chains	1
Total formula weight	150100.86
Authors	Parey, K.,Januliene, D.,Gewering, T.,Urbatsch, I.,Zhang, Q.,Moeller, A. (deposition date: 2022-04-12, release date: 2023-04-26, Last modification date: 2024-03-20)
Primary citation	Gewering, T.,Waghray, D.,Parey, K.,Jung, H.,Tran, N.N.B.,Zapata, J.,Zhao, P.,Chen, H.,Januliene, D.,Hummer, G.,Urbatsch, I.,Moeller, A.,Zhang, Q. Tracing the substrate translocation mechanism in P-glycoprotein. Elife, 12:-, 2024 Cited by PubMed: 38259172 DOI: 10.7554/eLife.90174 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (2.9 Å)

Structure validation