7ZIH

Crystal structure of human tryptophan hydroxylase 1 in complex with inhibitor AG-01-128

7ZIH の概要

• エントリーDOI: 10.2210/pdb7zih/pdb
• 分子名称: Tryptophan 5-hydroxylase 1, FE (III) ION, 8-(1~{H}-benzimidazol-2-ylmethyl)-3-ethyl-7-(phenylmethyl)purine-2,6-dione, ... (6 entities in total)
• 機能のキーワード: tryptophan hydroxylase, serotonin biosynthesis, metal binding protein
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 38079.09

構造登録者

Schuetz, A.,Gogolin, A.,Pfeifer, J.,Mallow, K.,Nazare, M.,Specker, E.,Heinemann, U. (登録日: 2022-04-08, 公開日: 2022-09-07, 最終更新日: 2024-01-31)

• 主引用文献: Specker, E.,Matthes, S.,Wesolowski, R.,Schutz, A.,Grohmann, M.,Alenina, N.,Pleimes, D.,Mallow, K.,Neuenschwander, M.,Gogolin, A.,Weise, M.,Pfeifer, J.,Ziebart, N.,Heinemann, U.,von Kries, J.P.,Nazare, M.,Bader, M.; Structure-Based Design of Xanthine-Benzimidazole Derivatives as Novel and Potent Tryptophan Hydroxylase Inhibitors.; J.Med.Chem., 65:11126-11149, 2022; PubMed: 35921615; DOI: 10.1021/acs.jmedchem.2c00598

実験手法

X-RAY DIFFRACTION (1.46890830792 Å)