7ZID

Crystal Structure of truncated aspartate transcarbamoylase from Plasmodium falciparum in complex with BDA-14

7ZID の概要

• エントリーDOI: 10.2210/pdb7zid/pdb
• 関連するBIRD辞書のPRD_ID: PRD_002386
• 分子名称: Aspartate carbamoyltransferase, GLYCEROL, SULFATE ION, ... (5 entities in total)
• 機能のキーワード: aspartate transcarbamoylase, plasmodium falciparum, fragment-based screening, inhibitor., transferase
• 由来する生物種: Plasmodium falciparum 3D7
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 121791.04

構造登録者

Wang, C.,Zhang, B. (登録日: 2022-04-07, 公開日: 2022-08-31, 最終更新日: 2024-01-31)

• 主引用文献: Wang, C.,Zhang, B.,Kruger, A.,Du, X.,Visser, L.,Domling, A.S.S.,Wrenger, C.,Groves, M.R.; Discovery of Small-Molecule Allosteric Inhibitors of Pf ATC as Antimalarials.; J.Am.Chem.Soc., 144:19070-19077, 2022; PubMed: 36195578; DOI: 10.1021/jacs.2c08128

実験手法

X-RAY DIFFRACTION (2.55 Å)