7ZFR

Crystal structure of HLA-DP (DPA1*02:01-DPB1*01:01) in complex with a peptide bound in the reverse direction

Summary for 7ZFR

• Entry DOI: 10.2210/pdb7zfr/pdb
• Related: 7ZAK
• Descriptor: MHC class II HLA-DP alpha chain (DPA1*02:01), MHC class II HLA-DP beta chain (DPB1*01:01), Synthetic peptide, ... (4 entities in total)
• Functional Keywords: hla class ii, human leukocyte antigen class ii, mhc class ii, major histocompatibility complex class ii, immune system
• Biological source: Homo sapiens; More
• Total number of polymer chains: 3
• Total formula weight: 61440.16

Authors

Racle, J.,Guillaume, P.,Larabi, A.,Lau, K.,Pojer, F.,Gfeller, D. (deposition date: 2022-04-01, release date: 2023-04-12, Last modification date: 2024-02-07)

• Primary citation: Racle, J.,Guillaume, P.,Schmidt, J.,Michaux, J.,Larabi, A.,Lau, K.,Perez, M.A.S.,Croce, G.,Genolet, R.,Coukos, G.,Zoete, V.,Pojer, F.,Bassani-Sternberg, M.,Harari, A.,Gfeller, D.; Machine learning predictions of MHC-II specificities reveal alternative binding mode of class II epitopes.; Immunity, 56:1359-1375.e13, 2023; PubMed: 37023751; DOI: 10.1016/j.immuni.2023.03.009

Experimental method

X-RAY DIFFRACTION (2.9 Å)