7ZCZ
Crystal Structure of truncated aspartate transcarbamoylase from Plasmodium falciparum with bound inhibitor 1-(4-chlorophenyl)methanamine
Summary for 7ZCZ
Entry DOI | 10.2210/pdb7zcz/pdb |
Descriptor | Aspartate carbamoyltransferase, 1-(4-CHLOROPHENYL)METHANAMINE, SULFATE ION, ... (5 entities in total) |
Functional Keywords | aspartate transcarbamoylase, plasmodium falciparum, fragment-based screening, inhibitor., transferase |
Biological source | Plasmodium falciparum 3D7 |
Total number of polymer chains | 3 |
Total formula weight | 121646.66 |
Authors | |
Primary citation | Wang, C.,Zhang, B.,Kruger, A.,Du, X.,Visser, L.,Domling, A.S.S.,Wrenger, C.,Groves, M.R. Discovery of Small-Molecule Allosteric Inhibitors of Pf ATC as Antimalarials. J.Am.Chem.Soc., 144:19070-19077, 2022 Cited by PubMed: 36195578DOI: 10.1021/jacs.2c08128 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.45 Å) |
Structure validation
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