7ZAE

BRD4 in complex with FragLite15

This is a non-PDB format compatible entry.

Summary for 7ZAE

• Entry DOI: 10.2210/pdb7zae/pdb
• Descriptor: Isoform C of Bromodomain-containing protein 4, GLYCEROL, 4-bromanyl-2-methoxy-pyridine, ... (4 entities in total)
• Functional Keywords: brd4, inhibitor, fragment, bromodomain, fraglite, transcription
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 15666.79

Authors

Turberville, S.,Martin, M.P.,Hope, I.,Noble, M.E.M. (deposition date: 2022-03-22, release date: 2022-11-23, Last modification date: 2024-01-31)

• Primary citation: Davison, G.,Martin, M.P.,Turberville, S.,Dormen, S.,Heath, R.,Heptinstall, A.B.,Lawson, M.,Miller, D.C.,Ng, Y.M.,Sanderson, J.N.,Hope, I.,Wood, D.J.,Cano, C.,Endicott, J.A.,Hardcastle, I.R.,Noble, M.E.M.,Waring, M.J.; Mapping Ligand Interactions of Bromodomains BRD4 and ATAD2 with FragLites and PepLites─Halogenated Probes of Druglike and Peptide-like Molecular Interactions.; J.Med.Chem., 65:15416-15432, 2022; PubMed: 36367089; DOI: 10.1021/acs.jmedchem.2c01357

Experimental method

X-RAY DIFFRACTION (1.1 Å)