Summary for 7ZA8
Entry DOI | 10.2210/pdb7za8/pdb |
Descriptor | Isoform C of Bromodomain-containing protein 4, 4-bromanyl-1~{H}-pyridin-2-one (3 entities in total) |
Functional Keywords | brd4, inhibitor, fragment, bromodomain, fraglite, transcription |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 1 |
Total formula weight | 15642.57 |
Authors | Turberville, S.,Martin, M.P.,Hope, I.,Noble, M.E.M. (deposition date: 2022-03-22, release date: 2022-12-07, Last modification date: 2024-01-31) |
Primary citation | Davison, G.,Martin, M.P.,Turberville, S.,Dormen, S.,Heath, R.,Heptinstall, A.B.,Lawson, M.,Miller, D.C.,Ng, Y.M.,Sanderson, J.N.,Hope, I.,Wood, D.J.,Cano, C.,Endicott, J.A.,Hardcastle, I.R.,Noble, M.E.M.,Waring, M.J. Mapping Ligand Interactions of Bromodomains BRD4 and ATAD2 with FragLites and PepLites─Halogenated Probes of Druglike and Peptide-like Molecular Interactions. J.Med.Chem., 65:15416-15432, 2022 Cited by PubMed: 36367089DOI: 10.1021/acs.jmedchem.2c01357 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.04 Å) |
Structure validation
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