7Z5L

Crystal structure of human insulin, crystallised in the presence of macrophage migration inhibitory factor (MIF) and dimethyl sulfoxide (DMSO)

Summary for 7Z5L

• Entry DOI: 10.2210/pdb7z5l/pdb
• Descriptor: Insulin A chain, Insulin B chain, SULFATE ION, ... (5 entities in total)
• Functional Keywords: insulin glucose metabolism macrophage migration inhibitory factor, hormone
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 2
• Total formula weight: 6097.90

Authors

van den Elsen, J.M.H.,Wahid, A.A.,Crennell, C. (deposition date: 2022-03-09, release date: 2023-03-22, Last modification date: 2024-02-07)

• Primary citation: Wahid, A.A.,Kasaar, O.,Ronsse, D.,Smith, K.,Hyland, A.,Staddon, W.,Scrivens, B.,Babarinde, S.O.,Dunphy, R.,Cozier, G.E.,Koumanov, F.,Crennell, S.J.,Williams, R.J.,van den Elsen, J.M.H.; Dissociation of Hexameric Insulin Facilitated by Macrophage Migration Inhibitory Factor Indicates a Novel Role in Insulin Signalling; To Be Published,

Experimental method

X-RAY DIFFRACTION (1.4 Å)