7Z5L
Crystal structure of human insulin, crystallised in the presence of macrophage migration inhibitory factor (MIF) and dimethyl sulfoxide (DMSO)
Summary for 7Z5L
Entry DOI | 10.2210/pdb7z5l/pdb |
Descriptor | Insulin A chain, Insulin B chain, SULFATE ION, ... (5 entities in total) |
Functional Keywords | insulin glucose metabolism macrophage migration inhibitory factor, hormone |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 2 |
Total formula weight | 6097.90 |
Authors | van den Elsen, J.M.H.,Wahid, A.A.,Crennell, C. (deposition date: 2022-03-09, release date: 2023-03-22, Last modification date: 2024-02-07) |
Primary citation | Wahid, A.A.,Kasaar, O.,Ronsse, D.,Smith, K.,Hyland, A.,Staddon, W.,Scrivens, B.,Babarinde, S.O.,Dunphy, R.,Cozier, G.E.,Koumanov, F.,Crennell, S.J.,Williams, R.J.,van den Elsen, J.M.H. Dissociation of Hexameric Insulin Facilitated by Macrophage Migration Inhibitory Factor Indicates a Novel Role in Insulin Signalling To Be Published, |
Experimental method | X-RAY DIFFRACTION (1.4 Å) |
Structure validation
Download full validation report