7Z5L

Crystal structure of human insulin, crystallised in the presence of macrophage migration inhibitory factor (MIF) and dimethyl sulfoxide (DMSO)

7Z5L の概要

• エントリーDOI: 10.2210/pdb7z5l/pdb
• 分子名称: Insulin A chain, Insulin B chain, SULFATE ION, ... (5 entities in total)
• 機能のキーワード: insulin glucose metabolism macrophage migration inhibitory factor, hormone
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 6097.90

構造登録者

van den Elsen, J.M.H.,Wahid, A.A.,Crennell, C. (登録日: 2022-03-09, 公開日: 2023-03-22, 最終更新日: 2024-02-07)

• 主引用文献: Wahid, A.A.,Kasaar, O.,Ronsse, D.,Smith, K.,Hyland, A.,Staddon, W.,Scrivens, B.,Babarinde, S.O.,Dunphy, R.,Cozier, G.E.,Koumanov, F.,Crennell, S.J.,Williams, R.J.,van den Elsen, J.M.H.; Dissociation of Hexameric Insulin Facilitated by Macrophage Migration Inhibitory Factor Indicates a Novel Role in Insulin Signalling; To Be Published,

実験手法

X-RAY DIFFRACTION (1.4 Å)