7Z2G

Cryo-EM structure of HIV-1 reverse transcriptase with a DNA aptamer in complex with doravirine

Summary for 7Z2G

• Entry DOI: 10.2210/pdb7z2g/pdb
• Related: 7Z24 7Z29 7Z2D 7Z2E
• EMDB information: 14457 14458 14462 14463 14465
• Descriptor: Reverse transcriptase/ribonuclease H, DNA (38-MER), 3-chloro-5-({1-[(4-methyl-5-oxo-4,5-dihydro-1H-1,2,4-triazol-3-yl)methyl]-2-oxo-4-(trifluoromethyl)-1,2-dihydropyridin-3-yl}oxy)benzonitrile, ... (4 entities in total)
• Functional Keywords: reverse transcriptase, rt-aptamer complex, non-nucleoside inhibitor, nnrti, transferase
• Biological source: Human immunodeficiency virus type 1 BH10; More
• Total number of polymer chains: 3
• Total formula weight: 126242.13

Authors

Singh, A.K.,Das, K. (deposition date: 2022-02-26, release date: 2022-07-20, Last modification date: 2022-10-12)

• Primary citation: Singh, A.K.,De Wijngaert, B.,Bijnens, M.,Uyttersprot, K.,Nguyen, H.,Martinez, S.E.,Schols, D.,Herdewijn, P.,Pannecouque, C.,Arnold, E.,Das, K.; Cryo-EM structures of wild-type and E138K/M184I mutant HIV-1 RT/DNA complexed with inhibitors doravirine and rilpivirine.; Proc.Natl.Acad.Sci.USA, 119:e2203660119-e2203660119, 2022; PubMed: 35858448; DOI: 10.1073/pnas.2203660119

Experimental method

ELECTRON MICROSCOPY (3.65 Å)