7Z24
Cryo-EM structure of HIV-1 reverse transcriptase with a DNA aptamer in complex with nevirapine
Summary for 7Z24
Entry DOI | 10.2210/pdb7z24/pdb |
EMDB information | 14457 |
Descriptor | Reverse transcriptase/ribonuclease H, DNA (38-mer), 11-CYCLOPROPYL-5,11-DIHYDRO-4-METHYL-6H-DIPYRIDO[3,2-B:2',3'-E][1,4]DIAZEPIN-6-ONE, ... (4 entities in total) |
Functional Keywords | reverse transcriptase, rt-aptamer complex, non-nucleoside inhibitor, p51, p66, transferase |
Biological source | Human immunodeficiency virus type 1 BH10 More |
Total number of polymer chains | 3 |
Total formula weight | 126082.68 |
Authors | Singh, A.K.,Das, K. (deposition date: 2022-02-25, release date: 2022-07-20, Last modification date: 2022-08-03) |
Primary citation | Singh, A.K.,De Wijngaert, B.,Bijnens, M.,Uyttersprot, K.,Nguyen, H.,Martinez, S.E.,Schols, D.,Herdewijn, P.,Pannecouque, C.,Arnold, E.,Das, K. Cryo-EM structures of wild-type and E138K/M184I mutant HIV-1 RT/DNA complexed with inhibitors doravirine and rilpivirine. Proc.Natl.Acad.Sci.USA, 119:e2203660119-e2203660119, 2022 Cited by PubMed: 35858448DOI: 10.1073/pnas.2203660119 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (3.32 Å) |
Structure validation
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