7Z1W

PARP15 catalytic domain in complex with OUL246

Summary for 7Z1W

Entry DOI	10.2210/pdb7z1w/pdb
Related	7R3O 7R4A 7R5D 7Z1V
Descriptor	Protein mono-ADP-ribosyltransferase PARP15, 6-chloranyl-[1,2,4]triazolo[3,4-b][1,3]benzothiazole, DIMETHYL SULFOXIDE, ... (4 entities in total)
Functional Keywords	parp, inhibitor, complex, transferase
Biological source	Homo sapiens (human)
Total number of polymer chains	2
Total formula weight	51166.71
Authors	Maksimainen, M.M.,Lehtio, L. (deposition date: 2022-02-25, release date: 2023-01-25, Last modification date: 2024-02-07)
Primary citation	Murthy, S.,Nizi, M.G.,Maksimainen, M.M.,Massari, S.,Alaviuhkola, J.,Lippok, B.E.,Vagaggini, C.,Sowa, S.T.,Galera-Prat, A.,Ashok, Y.,Venkannagari, H.,Prunskaite-Hyyrylainen, R.,Dreassi, E.,Luscher, B.,Korn, P.,Tabarrini, O.,Lehtio, L. [1,2,4]Triazolo[3,4- b ]benzothiazole Scaffold as Versatile Nicotinamide Mimic Allowing Nanomolar Inhibition of Different PARP Enzymes. J.Med.Chem., 66:1301-1320, 2023 Cited by PubMed: 36598465 DOI: 10.1021/acs.jmedchem.2c01460 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.9 Å)

Structure validation