7Z12

VAR2 complex with PAM1.4

Summary for 7Z12

Entry DOI	10.2210/pdb7z12/pdb
EMDB information	14438
Descriptor	PAM1.4, Heavy Chain, PAM1.4, light Chain, VAR2CSA (3 entities in total)
Functional Keywords	var2csa, malaria, cell adhesion
Biological source	Homo sapiens More
Total number of polymer chains	3
Total formula weight	312339.23
Authors	Raghavan, S.S.R.,Wang, K.T. (deposition date: 2022-02-24, release date: 2022-11-02, Last modification date: 2022-11-30)
Primary citation	Raghavan, S.S.R.,Dagil, R.,Lopez-Perez, M.,Conrad, J.,Bassi, M.R.,Quintana, M.D.P.,Choudhary, S.,Gustavsson, T.,Wang, Y.,Gourdon, P.,Ofori, M.F.,Christensen, S.B.,Minja, D.T.R.,Schmiegelow, C.,Nielsen, M.A.,Barfod, L.,Hviid, L.,Salanti, A.,Lavstsen, T.,Wang, K. Cryo-EM reveals the conformational epitope of human monoclonal antibody PAM1.4 broadly reacting with polymorphic malarial protein VAR2CSA. Plos Pathog., 18:e1010924-e1010924, 2022 Cited by PubMed: 36383559 DOI: 10.1371/journal.ppat.1010924 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3 Å)

Structure validation