7YY2

Crystal structure of Mycobacterium abscessus Phosphopantetheine adenylyltransferase in complex with Compound 20

7YY2 の概要

• エントリーDOI: 10.2210/pdb7yy2/pdb
• 分子名称: Phosphopantetheine adenylyltransferase, 5-[3-(1~{H}-indol-3-yl)propoxy]-1-phenyl-pyrazole-4-carboxylic acid (3 entities in total)
• 機能のキーワード: coad, ppat, nucleotidyltransferase, coenzyme a biosynthesis, transferase
• 由来する生物種: Mycobacteroides abscessus
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 53514.84

構造登録者

Thomas, S.E.,Coyne, A.G.,Blundell, T.L. (登録日: 2022-02-17, 公開日: 2022-06-29, 最終更新日: 2024-01-31)

• 主引用文献: Thomas, S.E.,McCarthy, W.J.,El Bakali, J.,Brown, K.P.,Kim, S.Y.,Blaszczyk, M.,Mendes, V.,Abell, C.,Floto, R.A.,Coyne, A.G.,Blundell, T.L.; Structural Characterization of Mycobacterium abscessus Phosphopantetheine Adenylyl Transferase Ligand Interactions: Implications for Fragment-Based Drug Design.; Front Mol Biosci, 9:880432-880432, 2022; PubMed: 35712348; DOI: 10.3389/fmolb.2022.880432

実験手法

X-RAY DIFFRACTION (1.598 Å)