7YMK

Estrogen Receptor Alpha Ligand Binding Domain C381S C417S Y537S Mutant in Complex with an Covalent Selective Estrogen Receptor Degrader 29c and GRIP Peptide

Summary for 7YMK

• Entry DOI: 10.2210/pdb7ymk/pdb
• Descriptor: Estrogen receptor, Grip peptide, DI(HYDROXYETHYL)ETHER, ... (6 entities in total)
• Functional Keywords: complex, inhibitor, estrogen receptor alpha, transcription-inhibitor complex, transcription, transcription/inhibitor
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 4
• Total formula weight: 60845.16

Authors

Min, J.,Hu, H.B.,Yang, Y.,Dong, C.E.,Zhou, H.B.,Chen, C.-C.,Guo, R.-T. (deposition date: 2022-07-28, release date: 2023-05-31, Last modification date: 2023-12-20)

• Primary citation: Wang, Y.,Min, J.,Deng, X.,Feng, T.,Hu, H.,Guo, X.,Cheng, Y.,Xie, B.,Yang, Y.,Chen, C.C.,Guo, R.T.,Dong, C.,Zhou, H.B.; Discovery of novel covalent selective estrogen receptor degraders against endocrine-resistant breast cancer.; Acta Pharm Sin B, 13:4963-4982, 2023; PubMed: 38045063; DOI: 10.1016/j.apsb.2023.05.005

Experimental method

X-RAY DIFFRACTION (2.25 Å)