7YF5

Crystal Structure of the UDPGA Binding Domain of the Human Phase II Metabolizing Enzyme UDP-Glucuronosyltransferase 2B10

Summary for 7YF5

• Entry DOI: 10.2210/pdb7yf5/pdb
• Descriptor: UDP-glucuronosyltransferase 2B10, SULFATE ION (3 entities in total)
• Functional Keywords: udp-glucuronosyltransferase, ugt, 2b10, udpga, transferase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 38360.13

Authors

Yin, X.L.,Tong, J.S. (deposition date: 2022-07-07, release date: 2023-07-12, Last modification date: 2024-01-24)

Primary citation

Yin, X.,Lu, X.,Qi, X.,Tu, Y.,Zhang, N.,Yang, Y.,Chen, X.,Tong, J.
Crystal Structure Determination of Nucleotide-sugar Binding Domain of Human UDP-glucuronosyltransferases 2B10.
Protein Pept.Lett., 30:941-950, 2023

PubMed Abstract: UDP-glucuronosyltransferases (UGTs) play a crucial role in maintaining endobiotic homeostasis and metabolizing xenobiotic compounds, particularly clinical drugs. However, the detailed catalytic mechanism of UGTs has not been fully elucidated due to the limited availability of reliable protein structures. Determining the catalytic domain of human UGTs has proven to be a significant challenge, primarily due to the difficulty in purifying and crystallizing the full-length protein.

PubMed: 37946357
DOI: 10.2174/0109298665255492231020050937

Experimental method

X-RAY DIFFRACTION (1.527 Å)