7YF5

Crystal Structure of the UDPGA Binding Domain of the Human Phase II Metabolizing Enzyme UDP-Glucuronosyltransferase 2B10

7YF5 の概要

• エントリーDOI: 10.2210/pdb7yf5/pdb
• 分子名称: UDP-glucuronosyltransferase 2B10, SULFATE ION (3 entities in total)
• 機能のキーワード: udp-glucuronosyltransferase, ugt, 2b10, udpga, transferase
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 38360.13

構造登録者

Yin, X.L.,Tong, J.S. (登録日: 2022-07-07, 公開日: 2023-07-12, 最終更新日: 2024-01-24)

主引用文献

Yin, X.,Lu, X.,Qi, X.,Tu, Y.,Zhang, N.,Yang, Y.,Chen, X.,Tong, J.
Crystal Structure Determination of Nucleotide-sugar Binding Domain of Human UDP-glucuronosyltransferases 2B10.
Protein Pept.Lett., 30:941-950, 2023

PubMed Abstract: UDP-glucuronosyltransferases (UGTs) play a crucial role in maintaining endobiotic homeostasis and metabolizing xenobiotic compounds, particularly clinical drugs. However, the detailed catalytic mechanism of UGTs has not been fully elucidated due to the limited availability of reliable protein structures. Determining the catalytic domain of human UGTs has proven to be a significant challenge, primarily due to the difficulty in purifying and crystallizing the full-length protein.

PubMed: 37946357
DOI: 10.2174/0109298665255492231020050937

実験手法

X-RAY DIFFRACTION (1.527 Å)