7YBO

Crystal structure of FGFR4 kinase domain with 10z

7YBO の概要

• エントリーDOI: 10.2210/pdb7ybo/pdb
• 分子名称: Fibroblast growth factor receptor 4, ~{N}-[4-[(1~{R})-1-[3,5-bis(chloranyl)pyridin-4-yl]ethoxy]-5-cyano-pyridin-2-yl]-6-bromanyl-5-(hydroxymethyl)-1-(2-morpholin-4-ylethyl)pyrrolo[3,2-b]pyridine-3-carboxamide, SULFATE ION, ... (4 entities in total)
• 機能のキーワード: kinase, inhibitor, structural protein, transferase-transferase inhibitor complex, transferase, transferase-inhibitor complex, transferase/inhibitor
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 35944.78

構造登録者

Chen, X.J.,Lin, Q.M.,Chen, Y.H. (登録日: 2022-06-29, 公開日: 2022-11-16, 最終更新日: 2023-11-29)

• 主引用文献: Yang, F.,Chen, X.,Song, X.,Ortega, R.,Lin, X.,Deng, W.,Guo, J.,Tu, Z.,Patterson, A.V.,Smaill, J.B.,Chen, Y.,Lu, X.; Design, Synthesis, and Biological Evaluation of 5-Formyl-pyrrolo[3,2- b ]pyridine-3-carboxamides as New Selective, Potent, and Reversible-Covalent FGFR4 Inhibitors.; J.Med.Chem., 65:14809-14831, 2022; PubMed: 36278929; DOI: 10.1021/acs.jmedchem.2c01319

実験手法

X-RAY DIFFRACTION (2.307 Å)