7YBL

SARS-CoV-2 B.1.620 variant spike (close state)

7YBL の概要

• エントリーDOI: 10.2210/pdb7ybl/pdb
• EMDBエントリー: 33725
• 分子名称: Spike glycoprotein, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (5 entities in total)
• 機能のキーワード: sars-cov-2, lambda, spike, viral protein
• 由来する生物種: Severe acute respiratory syndrome coronavirus 2
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 445664.29

構造登録者

Wang, X.,Fu, W. (登録日: 2022-06-29, 公開日: 2023-08-09, 最終更新日: 2025-07-02)

主引用文献

Xing, X.,Wang, L.,Cui, Z.,Fu, W.,Zheng, T.,Qin, L.,Ge, P.,Qian, A.,Wang, N.,Yuan, S.
Structures of SARS-CoV-2 spike protein alert noteworthy sites for the potential approaching variants.
Virol Sin, 37:938-941, 2022

PubMed Abstract: • Deletion of residues 156–157 warps the neighboring beta-sheet and leads NTD and RBD to shift. • T859N stabilizes the packing of the 630 loop motif to make RBD standing transition more difficult. • The overall structures of the closed state S complex from different variants resemble each other. • Mutations in FPPR may affect the overall structure of the trimeric spike protein.

PubMed: 36368512
DOI: 10.1016/j.virs.2022.11.003

実験手法

ELECTRON MICROSCOPY (3.6 Å)