7YAE

Octreotide-bound SSTR2-Gi complex

7YAE の概要

• エントリーDOI: 10.2210/pdb7yae/pdb
• EMDBエントリー: 33710
• 分子名称: Guanine nucleotide-binding protein G(i) subunit alpha-1, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... (7 entities in total)
• 機能のキーワード: agonist, membrane protein, complex, signaling protein
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 158698.19

構造登録者

Zhao, J.,Shao, Z. (登録日: 2022-06-28, 公開日: 2023-04-19)

• 主引用文献: Zhao, J.,Fu, H.,Yu, J.,Hong, W.,Tian, X.,Qi, J.,Sun, S.,Zhao, C.,Wu, C.,Xu, Z.,Cheng, L.,Chai, R.,Yan, W.,Wei, X.,Shao, Z.; Prospect of acromegaly therapy: molecular mechanism of clinical drugs octreotide and paltusotine.; Nat Commun, 14:962-962, 2023; PubMed: 36810324; DOI: 10.1038/s41467-023-36673-z

実験手法

ELECTRON MICROSCOPY (3.37 Å)