7Y4U

Crystal structure of cMET kinase domain bound by compound 9Y

7Y4U の概要

• エントリーDOI: 10.2210/pdb7y4u/pdb
• 分子名称: Hepatocyte growth factor receptor, ~{N}-methyl-4-[1-[2-[3-(1-methylpyrazol-4-yl)quinolin-6-yl]ethyl]-6-oxidanylidene-pyridazin-3-yl]-2-(trifluoromethyl)benzamide (3 entities in total)
• 機能のキーワード: transferase inhibitor, transferase, transferase-inhibitor complex, transferase/inhibitor
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 35374.84

構造登録者

Qu, L.Z.,Chen, Y.H. (登録日: 2022-06-16, 公開日: 2022-11-23, 最終更新日: 2023-11-29)

• 主引用文献: Wang, C.,Li, J.,Qu, L.,Tang, X.,Song, X.,Yang, F.,Chen, X.,Lin, Q.,Lin, W.,Zhou, Y.,Tu, Z.,Chen, Y.,Zhang, Z.,Lu, X.; Discovery of D6808, a Highly Selective and Potent Macrocyclic c-Met Inhibitor for Gastric Cancer Harboring MET Gene Alteration Treatment.; J.Med.Chem., 65:15140-15164, 2022; PubMed: 36355693; DOI: 10.1021/acs.jmedchem.2c00981

実験手法

X-RAY DIFFRACTION (2.26 Å)