7Y4K

Crystal structure of Ricin A chain bound with N2-(2-amino-4-oxo-3,4-dihydropteridine-7-carbonyl)glycyl-L-phenylalanyl-N6-((benzyloxy)carbonyl)-L-ornitine

Summary for 7Y4K

• Entry DOI: 10.2210/pdb7y4k/pdb
• Descriptor: Ricin A chain, (2S)-2-[[(2S)-2-[2-[(2-azanyl-4-oxidanylidene-3H-pteridin-7-yl)carbonylamino]ethanoylamino]-3-phenyl-propanoyl]amino]-5-(phenylmethoxycarbonylamino)pentanoic acid, SULFATE ION, ... (4 entities in total)
• Functional Keywords: hydrolase inhibitor, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Ricinus communis (castor bean)
• Total number of polymer chains: 1
• Total formula weight: 31748.59

Authors

Katakura, S.,Goto, M.,Ohba, T.,Kawata, R.,Nagatsu, K.,Higashi, S.,Matsumoto, K.,Kurisu, K.,Ohtsuka, K.,Saito, R. (deposition date: 2022-06-15, release date: 2022-11-16, Last modification date: 2023-11-29)

• Primary citation: Saito, R.,Goto, M.,Katakura, S.,Ohba, T.,Kawata, R.,Nagatsu, K.,Higashi, S.,Kurisu, K.,Matsumoto, K.,Ohtsuka, K.; Pterin-based small molecule inhibitor capable of binding to the secondary pocket in the active site of ricin-toxin A chain.; Plos One, 17:e0277770-e0277770, 2022; PubMed: 36508422; DOI: 10.1371/journal.pone.0277770

Experimental method

X-RAY DIFFRACTION (1.7 Å)