7Y3S

Controlling fibrosis using compound with novel binding mode to prolyl-tRNA synthetase 1

7Y3S の概要

• エントリーDOI: 10.2210/pdb7y3s/pdb
• 分子名称: Bifunctional glutamate/proline--tRNA ligase, 1-(6-bromanyl-7-methyl-imidazo[4,5-b]pyridin-3-yl)-3-[(2R,3S)-3-oxidanylpiperidin-2-yl]propan-2-one, ADENOSINE-5'-TRIPHOSPHATE, ... (6 entities in total)
• 機能のキーワード: prolyl-trna synthetase, inhibitor, fibrosis, binding mode, translation, translation-inhibitor complex, translation/inhibitor
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 115263.04

構造登録者

Kim, S.,Yoon, I.,Son, J.,Park, S.,Hwang, K.Y. (登録日: 2022-06-12, 公開日: 2023-07-05, 最終更新日: 2023-11-29)

• 主引用文献: Yoon, I.,Kim, S.,Cho, M.,You, K.A.,Son, J.,Lee, C.,Suh, J.H.,Bae, D.J.,Kim, J.M.,Oh, S.,Park, S.,Kim, S.,Cho, S.H.,Park, S.,Bang, K.,Seo, M.,Kim, J.H.,Lee, B.,Park, J.S.,Hwang, K.Y.,Kim, S.; Control of fibrosis with enhanced safety via asymmetric inhibition of prolyl-tRNA synthetase 1.; Embo Mol Med, 15:e16940-e16940, 2023; PubMed: 37212275; DOI: 10.15252/emmm.202216940

実験手法

X-RAY DIFFRACTION (2.6 Å)